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Science 26 December 1969:
Vol. 166. no. 3913, pp. 1638 - 1640
DOI: 10.1126/science.166.3913.1638
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Articles

Self-Assembly of Qbeta and MS2 Phage Particles: Possible Function of Initiation Complexes

P. P. Hung 1, C. M. Ling 1, and L. R. Overby 1

1 Department of Molecular Biology, Abbott Laboratories, North Chicago, Illinois 60064

Four kinds of particles were reconstituted with RNA and protein from the genetically unrelated bacteriophages Qbeta and MS2, namely, two homologous and two heterologous, with respect to RNA and protein. However, once Qbeta RNA (or MS2 RNA) reacted with a few molecules of either Qbeta or MS2 protein to form a nucleoprotein complex (initiation complex), it formed a phagelike particle only with subsequent addition of the same protein.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)