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Science 19 December 1969:
Vol. 166. no. 3912, pp. 1510 - 1511
DOI: 10.1126/science.166.3912.1510
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Articles

Imidodiphosphate and Pyrophosphate: Possible Biological Significance of Similar Structures

Marlin Larsen 1, Roger Willett 1, and Ralph G. Yount 2

1 Department of Chemistry, Washington State University, Pullman 99163
2 Departments of Agricultural Chemistry and Chemistry, Washington State University

The structure of sodium imidodiphosphate has been determined by single crystal x-ray diffraction. The P-N-P bond angle (127.2°) and P-N bond distance (1.68 angstroms) are remarkably similar to newly refined values for the P-O-P bond angle (128.6°) and the bridging P-O bond distance (1.63 angstroms) of sodium pyrophosphate. This close similarity may explain why P-N-P linkages in algal "polyphosphates" escaped detection until recently and why adenosine triphosphate analogs with this linkage mimic adenosine triphosphate so closely.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Trimetal Site and Substrate Distortion in a Family II Inorganic Pyrophosphatase.
I. P. Fabrichniy, L. Lehtio, M. Tammenkoski, A. B. Zyryanov, E. Oksanen, A. A. Baykov, R. Lahti, and A. Goldman (2007)
J. Biol. Chem. 282, 1422-1431
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Structural Insights into the Catalytic Mechanism of Phosphate Ester Hydrolysis by dUTPase.
O. Barabas, V. Pongracz, J. Kovari, M. Wilmanns, and B. G. Vertessy (2004)
J. Biol. Chem. 279, 42907-42915
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Multidimensional NMR Identifies the Conformational Shift Essential for Catalytic Competence in the 60-kDa Drosophila melanogaster dUTPase Trimer.
Z. Dubrovay, Z. Gaspari, E. Hunyadi-Gulyas, K. F. Medzihradszky, A. Perczel, and B. G. Vertessy (2004)
J. Biol. Chem. 279, 17945-17950
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beta, gamma-Peroxy analogs of adenosine and guanosine triphosphate: synthesis and biological activity.
M. Rosendahl and N. Leonard (1982)
Science 215, 81-82
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Inhibition of Heavy Meromyosin by Purine Disulfide Analogs of Adenosine Triphosphate.
R. G. Yount, J. S. Frye, and K. R. O'Keefe (1973)
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