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Science 12 December 1969:
Vol. 166. no. 3911, pp. 1412 - 1413
DOI: 10.1126/science.166.3911.1412
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Articles

Hypobaric Hypoxia: Effects on Early Development of Tryptophan Oxygenase in Neonatal Rats

Ralph P. Francesconi 1 and Milton Mager 1

1 Biochemistry and Pharmacology Laboratory, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760

Despite a reduction in liver and body weights of neonatal rats born and reared at a simulated altitude of 5790 meters (oxygen pressure, 76.36 millimeters of mercury), the hepatic enzyme tryptophan oxygenase develops prematurely in these stressed animals as compared to controls reared at sea level. Also, the specific activities remain distinctly elevated through the first 9 days of age; thus, the competence for premature synthesis ot tryptophan oxygenase is confirmed in neonatal rats.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)