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Science 5 December 1969:
Vol. 166. no. 3910, pp. 1300 - 1301
DOI: 10.1126/science.166.3910.1300
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Articles

Vascular Smooth Muscle Reactivity in Normotensive and Hypertensive Rats

Sydney Spector 1, Jerome H. Fleisch 2, Harriet M. Maling 2, and Bernard B. Brodie 2

1 Roche Institute of Molecular Biology, Nutley, New Jersey 07110
2 Laboratory of Chemical Pharmacology, National Heart Institute, Bethesda, Maryland 20014

Aortic strips from spontaneously hypertensive rats were less responsive than normal animals to the contractile effects of norepinephrine, serotonin, and potassium chloride but more reactive to the relaxant effects of the stimulant of beta receptors, isoproterenol. Thus, hypertension is not the result of an absence of beta receptor or a hypersensitivity of the vascular smooth muscle.


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