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Science 21 November 1969:
Vol. 166. no. 3908, pp. 1007 - 1008
DOI: 10.1126/science.166.3908.1007
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Articles

Polyol Pathway in Aorta: Regulation by Hormones

Rex S. Clements Jr. 1, Anthony D. Morrison 1, and Albert I. Winfgrad 1

1 George S. Cox Medical Research Institute. Department of Medicine, University of Pennsylvaniia, Phiiladelphia

Aldose reductase is present in human and rabbit aortas and provides a mechanism whereby hyper-glycemia can alter the metabolism of the arterial wall. Aortic sorbitol concentration is regulated by ambient glucose concentration and is increased by epinephrine, isoproterenol, dibutyryl-3',5'-adenosine monophosphate, ouabain, and angiotensin II.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Diabetes Among Men in a General Population: Prevalence and Associated Physiological Findings.
L. D. Ostrander Jr, D. E. Lamphiear, and W. D. Block (1976)
Arch Intern Med 136, 415-420
   Abstract »    PDF »
Why Control Blood Glucose Levels?.
A. A. Rossini (1976)
Arch Surg 111, 229-233
   Abstract »    PDF »
Biochemical Precursors of Atherosclerosis: Studies in Apparently Healthy Men in a General Population, Tecumseh, Mich.
L. D. Ostrander Jr., D. E. Lamphiear, W. D. Block, B. C. Johnson, and F. H. Epstein (1974)
Arch Intern Med 134, 224-230
   Abstract »    PDF »


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