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Science 7 November 1969:
Vol. 166. no. 3906, pp. 761 - 763
DOI: 10.1126/science.166.3906.761
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Articles

Parasexual Cycle in Cultivated Human Somatic Cells

G. M. Martin 1 and C. A. Sprague 1

1 Department of Pathology, University of Washington School of Medicine, Seattle 98105

Somatic segregation for three different autosomes was demonstrated in two strains of human diploid fibroblasts derived from subjects known to be heterozygous for chromosomal variants. Recombinant diploid cells appeared within cultures of tetraploid clones isolted from mass cultures. Tetraploid cells regularly occur in mass cultures and within clones of diploid cells. Such a parasexual cycle (2nrarr4nrarr2n), with recombination of entire linkage groups, could from the basis of a beginning formal genetic analysis in man.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Malignancies After Hematopoietic Stem Cell Transplantation: Many Questions, Some Answers.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)