Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 7 November 1969:
Vol. 166. no. 3906, pp. 753 - 755
DOI: 10.1126/science.166.3906.753
Prev | Table of Contents | Next

Articles

Thymus and Reproduction: Sex-Linked Dysgenesia of the Gonad after Neonatal Thymectomy in Mice

Yasuaki Nishizuka 1 and Teruyo Sakakura 1

1 Laboratory of Experimental Pathology, Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya 464, Japan

Neonatal thymectomy of mice, when no ectopic thymus existed, constantly resulted in developmental arrest of the ovary but not of the testis; it also caused sterility in the female. The ovaries of thymectomized mice were extremely small and were characterized by absence of follicles and corpora lutea. Such an ovarian dysgenesia was observed when the mice were thymectomized at 3 days of age, but not at 7 days or later; it was prevented by thymus grafting.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The study of regulatory T cells and NKT cells in Japan: a historical perspective.
H. Arase and K.-i. Seino (2009)
Int. Immunol. 21, 1101-1103
   Abstract »    Full Text »    PDF »
Molecular orchestration of differentiation and function of regulatory T cells.
L.-F. Lu and A. Rudensky (2009)
Genes & Dev. 23, 1270-1282
   Abstract »    Full Text »    PDF »
Potential Roles of a Special CD8{alpha}{alpha}+ Cell Population and CC Chemokine Thymus-Expressed Chemokine in Ovulation Related Inflammation.
C. Zhou, J. Wu, J. Borillo, L. Torres, J. McMahon, and Y.-H. Lou (2009)
J. Immunol. 182, 596-603
   Abstract »    Full Text »    PDF »
The frequency of regulatory CD3+CD8+CD28-CD25+ T lymphocytes in human peripheral blood increases with age.
R. Simone, A. Zicca, and D. Saverino (2008)
J. Leukoc. Biol. 84, 1454-1461
   Abstract »    Full Text »    PDF »
Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells.
R. A. Clark, S. J. Huang, G. F. Murphy, I. G. Mollet, D. Hijnen, M. Muthukuru, C. F. Schanbacher, V. Edwards, D. M. Miller, J. E. Kim, et al. (2008)
J. Exp. Med. 205, 2221-2234
   Abstract »    Full Text »    PDF »
Regulatory CD4+CD25+Foxp3+ T Cells Selectively Inhibit the Spontaneous Form of Lymphopenia-Induced Proliferation of Naive T Cells.
C. J. Winstead, J. M. Fraser, and A. Khoruts (2008)
J. Immunol. 180, 7305-7317
   Abstract »    Full Text »    PDF »
Cutting Edge: Autoimmune Disease in Day 3 Thymectomized Mice Is Actively Controlled by Endogenous Disease-Specific Regulatory T Cells.
E. T. Samy, K. M. Wheeler, R. J. Roper, C. Teuscher, and K. S. K. Tung (2008)
J. Immunol. 180, 4366-4370
   Abstract »    Full Text »    PDF »
Nonredundant roles for Stat5a/b in directly regulating Foxp3.
Z. Yao, Y. Kanno, M. Kerenyi, G. Stephens, L. Durant, W. T. Watford, A. Laurence, G. W. Robinson, E. M. Shevach, R. Moriggl, et al. (2007)
Blood 109, 4368-4375
   Abstract »    Full Text »    PDF »
IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin.
R. A. Clark and T. S. Kupper (2007)
Blood 109, 194-202
   Abstract »    Full Text »    PDF »
Autoimmunity and pulmonary hypertension: a perspective.
M. R. Nicolls, L. Taraseviciene-Stewart, P. R. Rai, D. B. Badesch, and N. F. Voelkel (2005)
Eur. Respir. J. 26, 1110-1118
   Abstract »    Full Text »    PDF »
CD4+ regulatory cells as a potential immunotherapy.
Z. Fehervari and S. Sakaguchi (2005)
Phil Trans R Soc B 360, 1647-1661
   Abstract »    Full Text »    PDF »
Peripheral CD8+CD25+ T Lymphocytes from MHC Class II-Deficient Mice Exhibit Regulatory Activity.
B. Bienvenu, B. Martin, C. Auffray, C. Cordier, C. Becourt, and B. Lucas (2005)
J. Immunol. 175, 246-253
   Abstract »    Full Text »    PDF »
Deficiency of the Src Homology Region 2 Domain-Containing Phosphatase 1 (SHP-1) Causes Enrichment of CD4+CD25+ Regulatory T Cells.
J. D. Carter, G. M. Calabrese, M. Naganuma, and U. Lorenz (2005)
J. Immunol. 174, 6627-6638
   Abstract »    Full Text »    PDF »
Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter.
Y. Y. Wan and R. A. Flavell (2005)
PNAS 102, 5126-5131
   Abstract »    Full Text »    PDF »
CD4+CD45RBHi Interleukin-4 Defective T Cells Elicit Antral Gastritis and Duodenitis.
T. Dohi, K. Fujihashi, T. Koga, Y. Etani, N. Yoshino, Y. I. Kawamura, and J. R. McGhee (2004)
Am. J. Pathol. 165, 1257-1268
   Abstract »    Full Text »    PDF »
Aod1 Controlling Day 3 Thymectomy-Induced Autoimmune Ovarian Dysgenesis in Mice Encompasses Two Linked Quantitative Trait Loci with Opposing Allelic Effects on Disease Susceptibility.
R. J. Roper, R. D. McAllister, J. E. Biggins, S. D. Michael, S. H. Min, K. S. K. Tung, S. B. Call, J. Gao, and C. Teuscher (2003)
J. Immunol. 170, 5886-5891
   Abstract »    Full Text »    PDF »
Maternal Autoantibody Triggers De Novo T Cell-Mediated Neonatal Autoimmune Disease.
Y. Y. Setiady, E. T. Samy, and K. S. K. Tung (2003)
J. Immunol. 170, 4656-4664
   Abstract »    Full Text »    PDF »
Interacting Quantitative Trait Loci Control Loss of Peripheral Tolerance and Susceptibility to Autoimmune Ovarian Dysgenesis After Day 3 Thymectomy in Mice.
R. J. Roper, R. Z. Ma, J. E. Biggins, R. J. Butterfield, S. D. Michael, K. S. K. Tung, R. W. Doerge, and C. Teuscher (2002)
J. Immunol. 169, 1640-1646
   Abstract »    Full Text »    PDF »
The Activity of Immunoregulatory T Cells Mediating Active Tolerance Is Potentiated in Nonobese Diabetic Mice by an IL-4-Based Retroviral Gene Therapy.
A. M. Yamamoto, Y. Chernajovsky, F. Lepault, O. Podhajcer, M. Feldmann, J.-F. Bach, and L. Chatenoud (2001)
J. Immunol. 166, 4973-4980
   Abstract »    Full Text »    PDF »
Neonatal thymectomy results in a repertoire enriched in T cells deleted in adult thymus.
H Smith, I. Chen, R Kubo, and K. Tung (1989)
Science 245, 749-752
   Abstract »    PDF »
Thymosin stimulates secretion of luteinizing hormone-releasing factor.
R. Rebar, A Miyake, T. Low, and A. Goldstein (1981)
Science 214, 669-671
   Abstract »    PDF »
Immunodeficiency Disease and Malignancy: Various Immunologic Deficiencies of Man and the Role of Immune Processes in the Control of Malignant Disease.
T. A. WALDMANN, W. STROBER, and R. M. BLAESE (1972)
Ann Intern Med 77, 605-628
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)