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Science 31 October 1969:
Vol. 166. no. 3905, pp. 620 - 621
DOI: 10.1126/science.166.3905.620
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Articles

Carcinogen-Induced Immune Depression: Absence in Mice Resistant to Chemical Oncogenesis

Osias Stutman 1

1 Department of Laboratory Medicine, College of Medical Sciences, University of Minnesota, Minneapolis

Administration of 3-methylcholanthrene 6 days before antigenic challenge depressed the immune response to sheep red cells in young adult mice (C3Hf/Bi strain) sensitive to the oncogenic effect of the drug (100 percent local tumors 240 days after carcinogen). The drug was not immunodepressant in the I strain, which is relatively resistant to its carcinogenic effect (11 percent local tumors 240 days after carcinogen).


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Susceptibility to the biological effects of polyaromatic hydrocarbons is influenced by genes of the major histocompatibility complex.
C. A. Elmets, M. Athar, K. A. Tubesing, D. Rothaupt, H. Xu, and H. Mukhtar (1998)
PNAS 95, 14915-14919
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Science. ISSN 0036-8075 (print), 1095-9203 (online)