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Science 24 October 1969:
Vol. 166. no. 3904, pp. 517 - 518
DOI: 10.1126/science.166.3904.517
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Articles

Antithrombin III: Protection against Death after Injection of Thromboplastin

Lewis T. Mann Jr. 1, Jens Chr. Jensenius 1, Morten Simonsen 1, and Ulrich Abildgaard 2

1 Institute for Experimental Immunology, Nørre allé 71, 2100 Copenhagen Ø, Denmark
2 Haematological Research Laboratory, Ullevaal Hospital, Oslo 1, Norway

Intravenous injection of autologous lipoprotein (thromboplastin) or thrombin produced a lethal, hemorrhagic syndrome in chicken embryos. The embryos could be protected from this fatal result by injection of antithrombin III, an alpha2-globulin (molecular weight 60,000 to 80,000) purified from human, bovine, and guinea pig blood. Heparin also protected the embryos, but other inhibitors were less protective.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Influence of Antithrombin III on Coagulation and Inflammation in Porcine Septic Shock.
G. Dickneite and B. Leithauser (1999)
Arterioscler Thromb Vasc Biol 19, 1566-1572
   Abstract »    Full Text »    PDF »
State-of-the-Art Review : Role of Antithrombin and Tissue Factor Pathway Inhibitor in the Control of Thrombosis and Mediation of Heparin Action.
N. Iverson and U. Abildgaard (1996)
Clinical and Applied Thrombosis/Hemostasis 2, 1-6
   Abstract »    PDF »


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