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Science 24 October 1969:
Vol. 166. no. 3904, pp. 510 - 512
DOI: 10.1126/science.166.3904.510
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Articles

Synaptic Current at the Squid Giant Synapse

Peter W. Gage 1 and John W. Moore 2

1 School of Physiology, University of New South Wales, Kensington, N.S.W., Australia
2 Department of Physiology and Pharmacology, Duke University, Durham, North Carolina, and Marine Biological Laboratory, Woods Hole, Massachusetts

Transmission in the giant synapse of squid was studied by measuring synaptic currents in the voltage-clamped postsynaptic giant axon. These currents varied linearly with the axon's membrane potential, and showed an intercept on the voltage axis at, or near, the sodium equilibrium potential. The intercept shifted in seawater containing less sodium by even more than the shift in the sodium equilibrium potential. It is concluded that the transmitter at this synapse causes a significant change in the sodium conductance only.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Proteins in Excitable Membranes.
D. Nachmansohn (1970)
Science 168, 1059-1066
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