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Science 17 October 1969:
Vol. 166. no. 3903, pp. 390 - 391
DOI: 10.1126/science.166.3903.390
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Articles

Human Diploid Cell Transformation by DNA Extracted from the Tumor Virus SV40

Stuart A. Aaronson 1 and George J. Todaro 1

1 Viral Carcinogenesis Branch, National Cancer Institute, Bethesda, Maryland 20014

The DNA isolated from simian virus 40 (SV40) can transform human fibroblast cells in tissue culture. Clonal lines of DNA-transformed human cells have been obtained that have properties characteristic of cells transformed by whole virus. They all contain SV40 T-antigen, and infectious virus can be recovered by cocultivation. This is the first demonstration of a permanent genetic alteration produced in human cells by purified DNA.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Gene Therapy for Human Genetic Disease?.
T. Friedmann and R. Roblin (1972)
Science 175, 949-955
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