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Science 10 October 1969:
Vol. 166. no. 3902, pp. 237 - 239
DOI: 10.1126/science.166.3902.237
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Articles

Lysergic Acid Diethylamide: Role in Conversion of Plasma Tryptophan to Brain Serotonin (5-Hydroxytryptamine)

Robert C. Lin 1, S. H. Ngai 1, and E. Costa 2

1 Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York-10032
2 Laboratory of Preclinical Pharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032

Injections of D-lysergic acid diethylamide decrease the turnover rate of 5-hydroxytryptamine of rat brain, as measured from the conversion of 14C-tryptophan into 14C-5-hydroxytryptamine. The 2-bromolysergic acid diethylamide given in doses fivefold greater than those of lysergic acid diethylamide fails to change the rate of 14C-tryptophan conversion into 14C-5-hydroxytryptamine. The effect of D-lysergic acid diethylamide is discussed with regard to its action on brain serotonergic neurons and its psychotomimetic effects.


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