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Science 26 September 1969:
Vol. 165. no. 3900, pp. 1371 - 1372
DOI: 10.1126/science.165.3900.1371
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Articles

Cytochrome P-420: Tubular Aggregates from Hepatic Microsomes

D. W. Shoeman 1, J. G. White 2, and G. J. Mannering 3

1 Department of Pharmacology, College of Medical Sciences, University of Minnesota, Minneapolis 55455
2 Department of Pediatrics, University of Minnesota
3 Department of Pharmacology, University of Minnesota

Aggregates were formed when clear supernatants from hepatic microsomes that had been treated with steapsin were desalted and concentrated. These aggregates contain large numbers of uniform tubular elements. These structures resemble microtubules seen in many cells but differ in their substructure. The aggregates were rich in cytochrome P-420. Unlike soluble cytochrome P-420, the cytochrome P-420 contained in the aggregates combines with drugs to give the characteristic difference spectra normally seen only with cytochrome P-450 contained in intact microsomes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Ultrastructural Features of Erythrocyte and Hemoglobin Sickling.
J. G. White (1974)
Arch Intern Med 133, 545-562
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