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Science 19 September 1969:
Vol. 165. no. 3899, pp. 1264 - 1266
DOI: 10.1126/science.165.3899.1264
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Articles

Diphosphonates Inhibit Formation of Calcium Phosphate Crystals in vitro and Pathological Calcification in vivo

Marion D. Francis 1, R. Graham 2, G. Russell 2, and Herbert Fleisch 2

1 Miami Valley Laboratories, The Procter & Gamble Company, Cincinnati, Ohio 45239
2 Department of Pathophysiology, University of Berne, Switzerland and Laboratory for Experimental Surgery, Davos, Switzerland

Two diphosphonates containing the P-C-P bond, CH3C(OH)(PO3HNa)2 and H2C(PO3HNa)2, inhibit the crystallization of calcium phosphate in vitro and prevent aortic calcification of rats given large amounts of vitamin D3. The diphosphonates therefore have effects similar to those described for compounds containing the P-O-P bond but are active when administered orally.


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