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Science 22 August 1969:
Vol. 165. no. 3895, pp. 810 - 811
DOI: 10.1126/science.165.3895.810
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Articles

Mammary Cancer Induction by 7,12-Dimethylbenz(a)anthraceue: Relation to Age

Thomas L. Dao 1

1 Department of Breast Surgery, Roswell Park Memorial Institute, New York State Department of Health, Bufalo 14203

Mammary glands were transplanted from donors treated with 7,12-dimethylbenz(a)anthracene to untreated isologous recipients. Incidence of mammary tumors in mammary grafts from 56-day-old donors was significantly higher than that in grafts from 120-day-old donors, regardless of the age of the recipient hosts. Whent mammary glands were transplanted from untreated donors to isologous recipients that subsequently received 7,12-dimethyl-benz(a)anthracene, a similar difference in tumor incidence in the grafts was observed. In contrast to mammary glands of older females, mammary glands of young adult female rats are highly vulnerable to the carcinogenic effect of 7,12-dimethylbenz(a)anthracene.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Susceptibility of Rats to Mammary Gland Carcinogenesis by the Food-Derived Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine (PhIP) Varies with Age and Is Associated with the Induction of Differential Gene Expression.
L. Shan, M. Yu, H. A.J. Schut, and E. G. Snyderwine (2004)
Am. J. Pathol. 165, 191-202
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Science. ISSN 0036-8075 (print), 1095-9203 (online)