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Science 15 August 1969:
Vol. 165. no. 3894, pp. 709 - 710
DOI: 10.1126/science.165.3894.709
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Articles

Serum Elastase Inhibitor Deficiency and agrl-Antitrypsin Deficiency in Patients with Obstructive Emphysema

Gerard M. Turino 1, Robert M. Senior 2, Bhagwan D. Garg 3, Steven Keller 3, Michael M. Levi 3, and Ines Mandl 3

1 Department of Medicine, Columbia University, College of Physician and Surgeons, and Presbyterian Hospital, New York
2 Division of Medicine, Walter Reed Army Institute of Research, Washington, D.C.
3 Columbia University, College of Physicians and Surgeons, and Francis Delafield Hospital, New York

A decreased inhibition of pancreatic elastase has been detected in the serums of six patients with agr1-antitrypsin deficiency. Five have severe clinical and physiological pulmonary emphysema. This observation extends the defect of inhibition by serum to a second, biologically active proteolytic enzyme in this form of familial emphysema.


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