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Science 8 August 1969:
Vol. 165. no. 3893, pp. 616 - 617
DOI: 10.1126/science.165.3893.616
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Articles

Epinephrine Metabolism in Mammalian Brain after Intravenous and Intraventricular Administration

Alan M. Steinman 1, Stanley E. Smerin 1, and Jack D. Barchas 1

1 Department of Psychiatry, School of Medicine, Stanford University, Stanford, California 94305

Epinephrine given intravenously or intraventricularly has a half-life in the brain of the rat of 2 to 2.5 hours. After intravenous administration of the drug the principal route of metabolism is O-methylation, whereas after intraventricular administration the principal route is conjugation.


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