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Science 8 August 1969:
Vol. 165. no. 3893, pp. 608 - 609
DOI: 10.1126/science.165.3893.608
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Articles

Turbidity, Birefringence, and Fluorescence Changes in Skeletal Muscle Coincident with the Action Potential

Laurence D. Carnay 1 and William H. Barry 1

1 Laboratory of Neurobiology, National Institute of Mental Health, Bethesda, Maryland 20014

Electrical stimulation of frog striated muscle was found to prduce trasient changes in turbidity. birefringence, and fluorescence (of fibers stained with pyronine B). The initial phase of these optical changes Was coinicident with the action potential. These findings suggest that there is a macromolecular conformational change in muscle membrane during excitation.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)