Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 1 August 1969:
Vol. 165. no. 3892, pp. 509 - 510
DOI: 10.1126/science.165.3892.509
Prev | Table of Contents | Next

Articles

Ventricular Arrhythmias Related to Antibiotic Usage in Dogs

Timothy J. Regan 1, Anthony J. Passannante 1, Henry A. Oldewurtel 1, and Mohammad I. Khan 1

1 New Jersey College of Medicine, 24 Baldwin Avenue, Jersey City 07304

In dogs, pretreatment with the macrolide antibiotic tylosin (5 milligrams per day per kilogram of body weight) increased the incidence of ventricular tachycardia and fibrillation during acute myocardial ischemia. Another group received a dose of acetyl strophanthidin which was nontoxic in controls, but which resulted in a ventricular arrhythmia in six of seven animals on antibiotic treatment. Enhancement of loss of potassium ion from the myocardium by the antibiotic was presumed to be related to the altered cardiac rhythm.

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)