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Science 1 August 1969:
Vol. 165. no. 3892, pp. 495 - 496
DOI: 10.1126/science.165.3892.495
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Articles

Induction in vitro of Microtubular Crystals by Vinca Alkaloids

Klaus G. Bensch 1, Robert Marantz 2, Henryk Wisniewski 2, and Michael Shelanski 2

1 Department of Pathology, Stanford University School of Medicine, Stanford, California 94304
2 Departments of Pharmacology and Pathology, Albert Einstein College of Medicine, Bronx, New York 10461

The addition of vinblastine or vincristine to solutions of pure microtubule protein or to supernatants from high-speed centrifugation of rabbit-brain homogenates results in the formation of a fine precipitate. Examination of this precipitate by electron microscopy reveals ordered structures with areas of ladder-like configuration.


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Postsynaptic Scaffolds of Excitatory and Inhibitory Synapses in Hippocampal Neurons: Maintenance of Core Components Independent of Actin Filaments and Microtubules.
D. W. Allison, A. S. Chervin, V. I. Gelfand, and A. M. Craig (2000)
J. Neurosci. 20, 4545-4554
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Microtubular Protein: Synthesis and Metabolism in Developing Brain.
G. R. Dutton and S. Barondes (1969)
Science 166, 1637-1638
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Science. ISSN 0036-8075 (print), 1095-9203 (online)