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Science 25 July 1969:
Vol. 165. no. 3891, pp. 405 - 407
DOI: 10.1126/science.165.3891.405
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Articles

25-Hydroxycholecalciferol: Direct Effect on Calcium Transport

E. B. Olson 1 and H. F. Deluca 1

1 Department of Biochemistry, University of Wisconsin, Madison 53706

The perfused small intestine from a vitamin D deficient rat exhibits about one-half the calcium transport of the intestine from a rat given vitamin D. These levels of calcium transport can be maintained for at least 4 hours. Addition of 2.5 micrograms of 25-hydroxycholecalciferol added to the vitamin D deficient intestine via the arterial blood perfusate induces a rise in calcium transport to +D levels within 2 hours. In contrast, 250 micrograms of vitamin D3 given in the same manner has no effect on the calcium transport level overa 4-hour period. These data provide strong evidence that 25-hydroxycholecalci ferol represents the metabolically active form of vitamin D3.


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Serum Parathyroid Hormone in X-Linked Hypophosphatemia.
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J. F. Myrtle and A. W. Norman (1971)
Science 171, 79-82
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The Nature of Vitamin D Resistance in Experimental Uremia.
D. V. Kimberg, R. D. Baerg, and E. Gershon (1970)
Arch Intern Med 126, 891-895
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Treatment of Renal Osteodystrophy With 25-Hydroxycholecalciferol.
H. F. DeLuca and L. V. Avioli (1970)
Arch Intern Med 126, 896-899
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Arrest of Hyperparathyroid Bone Disease with Dihydrotachysterol in Patients Undergoing Chronic Hemodialysis.
M. KAYE, G. CHATTERJEE, G. F. COHEN, and S. SAGAR (1970)
Ann Intern Med 73, 225-233
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Treatment of Vitamin D-Resistant Hypoparathyroidism With 25-Hydroxycholecalciferol.
C. Y. C. Pak, H. F. DeLuca, J. M. C. de los Rios, T. Suda, B. Ruskin, and C. S. Delea (1970)
Arch Intern Med 126, 239-247
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