Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 25 July 1969:
Vol. 165. no. 3891, pp. 402 - 403
DOI: 10.1126/science.165.3891.402
Prev | Table of Contents | Next

Articles

Renal Fructose-Metabolizing Enzymes: Significance in Hereditary Fructose Intolerance

Joseph F. Kranhold 1, Dana Loh 1, and R. Curtis Morris Jr. 1

1 Departments of Medicine and Pediatrics, Cancer Research Institute, University of California Medical Center, San Francisco 94122

In patients with hereditary fructose intolerance, which is characterized by deficient aldolase activity toward fructose-1-phosphate, fructose induces a renal tubular dysfunction that implicates only the proximal convoluted tubule. Because normal metabolism of fructose by way of fructose-1-phosphate requires fructokinase, aldolase "B," and triokinase, the exclusively cortical location of these enzymes indicates that the medulla is not involved in the metabolic abnormality presumably causal of the renal dysfunction.

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)