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Science 25 July 1969:
Vol. 165. no. 3891, pp. 400 - 402
DOI: 10.1126/science.165.3891.400
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Articles

Isopentenyladenosine Stimulates and Inhibits Mitosis of Human Lymphocytes Treated with Phytohemagglutinin

Robert C. Gallo 1, Jacqueline Whang-Peng 1, and Seymour Perry 1

1 Human Tumor Cell Biology Branch, National Cancer Institute, Bethesda, Maryland 20014

The plant cytokinin isopentenyladenosine, a component of yeast and mammalian transfer ribonucleic acid, is both a potent inhibitor and stimulator of DNA synthesis, transformation, and mitosis of the phytohemagglutinin-stimulated lymphocyte. The stage of the cell cycle and the concentrations used are critical for these effects. The addition of isopentenyladenosine within the first 12 hours after phytohemagglutinin at a concentration above 10-6 molar results in inhibition, while lower concentrations (between 10-7 and 10-6 molar), added at 24 hours or later, have a stimulatory effect.


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FASEB J 20, 412-418
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Science. ISSN 0036-8075 (print), 1095-9203 (online)