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Science 18 July 1969:
Vol. 165. no. 3890, pp. 291 - 292
DOI: 10.1126/science.165.3890.291
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Articles

Renin-Aldosterone System in Parkinson's Disease

André Barbeau 1, Lise Gillo-Joffroy 1, Roger Boucher 1, Wojciech Nowaczynski 1, and Jacques Genest 1

1 Montreal Clinical Research Institute and Hôtel-Dieu Hospital, University of Montreal, Montreal, Canada

Low blood pressure is frequent in the akinetic form of Parkinson's disease. A low renin activity in plasma as well as a low rate of aldosterone secretion is demonstrated in these patients. Renin activity in the plasma is further decreased by treatment with L-dihy-droxyphenylalanine, thus partially accouinting for the hypotensive episodes seen with this form of therapy.


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