Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 11 July 1969:
Vol. 165. no. 3889, pp. 196 - 199
DOI: 10.1126/science.165.3889.196
Prev | Table of Contents | Next

Articles

Hormonal Induction of Increased Zinc Uptake in Mammalian Cell Cultures: Requirement for RNA and Protein Synthesis

Rody P. Cox 1

1 Department of Medicine, New York University School of Medicine, New York 10016

The zinc content of HeLa S3 cells is markedly increased after growth in medium containing adrenal glucocorticoid hormones. Studies with inhibitors indicate that the synthesis of RNA and protein is required for enhanced zinc uptake. When protein synthesis is blocked in the presence of the steroid, an intermediate, presumably messenger RNA, which specifies enhanced zinc uptake accumulates and is expressed when the inhibition of protein synthesis is removed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Dexamethasone stimulation of metallothionein synthesis in HeLa cell cultures.
M Karin and H. Herschman (1979)
Science 204, 176-177
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)