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Science 4 July 1969:
Vol. 165. no. 3888, pp. 67 - 69
DOI: 10.1126/science.165.3888.67
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Articles

Tadpole Antibodies against Frog Hemoglobin and Their Effect on Development

George M. Maniatis 1, Lisa A. Steiner 1, and Vernon M. Ingram 1

1 Department of Biology, Massachusetts Institute of Technology, Cambridge 02139

Rana catesbeiana tadpoles immunized with the main hemoglobin component of the adult frog of the same species produced precipitating and agglutinating antibodies against the immunogen. After natural metamorphosis, the immunized froglets have as their only major hemoglobin a protein immunologically and electrophoretically different from the major hemoglobin of control froglets.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)