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Science 4 July 1969:
Vol. 165. no. 3888, pp. 63 - 65
DOI: 10.1126/science.165.3888.63
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Articles

Adenosine 3',5'-Monophosphate-Dependent Protein Kinase from Brain

Eishichi Miyamoto 1, J. F. Kuo 1, and Paul Greengard 1

1 Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510

Adenosine 3',5'-monophosphate at a concentration of 5 x 10-7 mole per liter causes a 400 percent increase in the rate of phosphorylation of histone catalyzed by a partially purified enzyme preparation from rabbit brain. The data provide the first direct evidence of a biochemical action of adenosine 3',5'-monophosphate in the brain.


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The Neurobiology of Slow Synaptic Transmission.
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Cell Communication, Calcium Ion, and Cyclic Adenosine Monophosphate.
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