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Science 20 June 1969:
Vol. 164. no. 3886, pp. 1412 - 1413
DOI: 10.1126/science.164.3886.1412
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Articles

Antigenic Changes in Lymph-Node Cells after Administration of Antiserum to Thymus Cells

Michael Schlesinger 1 and Ilana Yron 1

1 Department of Experimental Medicine and Cancer Research, Hebrew University-Hadassah Medical School, Jerusalem, Israel

Mice of the RIII and C57BL strains were treated with rabbit antiserum to thymus (ATS), and cells of their lymph nodes were analyzed serologi-cally at intervals after treatment. While lymph-node cells of untreated mice were sensitive to the cytotoxic effect of isoantibodies against the theta antigen, lymph-node cells of ATS-treated mice showed a significantly reduced sensitivity. Three days after ATS treatment lymph-node cells of most mice were completely refractory to the cytotoxic effect of theta antibodies. Administration of normal rabbit serum elicited only a slight reduction of the sensitivity of lymph-node cells to the cytotoxic effect of theta antibodies. The results support the hypothesis that ATS treatment selectively affects a population of thymus-dependent circulating lymphocytes.


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