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Science 13 June 1969:
Vol. 164. no. 3885, pp. 1295 - 1297
DOI: 10.1126/science.164.3885.1295
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Articles

LSD: Autoradiographic Study on the Placental Transfer and Tissue Distribution in Mice

Juhana E. Idanpaan-Heikkila 1 and Joseph C. Schoolar 1

1 Texas Research Institute, 1300 Moursund Avenue, Houston 77025

14C-lysergic acid diethylamide administered intravenously passed in a few minutes from the blood into the tissues. In addition to the brain, the adrenals, hypophysis, kidneys, liver, and lungs showed the highest uptake, much higher than the blood concentration. Excretion into the bile started immediately; this was the most inmportant elimination route. In the early stage of pregnancy, 2.5 percent (and in the late stage, 0.5 percent) of the radioactive dose passed the placental barrier into the fetus in 5 minutes. Over 70 percent of this fetal radioactivity was unchanged 15C-lysergic acid diethylamide.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
[3H]Lysergic Acid Diethylamide:Cellular Autoradiographic Localization in Rat Brain.
I. M. Diab, D. X. Freedman, and L. J. Roth (1971)
Science 173, 1022-1024
   Abstract »    PDF »
Social and Medical Aspects of Illicit Use of LSD.
J. Buckman (1971)
International Journal of Social Psychiatry 17, 163-176
   PDF »
LSD and Genetic Damage.
N. I. Dishotsky, W. D. Loughman, R. E. Mogar, and W. R. Lipscomb (1971)
Science 172, 431-440
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)