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Science 30 May 1969:
Vol. 164. no. 3883, pp. 1079 - 1080
DOI: 10.1126/science.164.3883.1079
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Articles

Lactate Dehydrogenase Isozymes in Human Cardiac Transplantation

James J. Nora 1, Denton A. Cooley 1, Barbara L. Johnson 1, Shirley C. Watson 1, and John D. Milam 1

1 Baylor University College of Medicine, Houston, Texas 77025

Lactate dehydrogenase (LDH) isozyme activities have been followed in 17 human cardiac allografts. A pattern of abnormality associated with cardiac rejection during the first month after operation has been determined: (i) LDH-1 activity is greater than LDH-2 activity; (ii) LDH-1 activity is greater than 35 percent of total LDH activity; and (iii) LDH-1 activity is greater than 100 international units. The LDH-1 abnormality helps to meet the need for an index of cardiac rejection during the early weeks after operation when the electro-cardiogram is least reliable.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)