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Science 30 May 1969:
Vol. 164. no. 3883, pp. 1077 - 1078
DOI: 10.1126/science.164.3883.1077
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Articles

Neoplastic Transformation in vitro of Hamster Lens Epithelium by Simian Virus 40

Daniel M. Albert 1, Alan S. Rabson 2, Patricia A. Grimes 3, and Ludwig von Sallmann 3

1 Ophthalmology Branch, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland 20014
2 Pathologic Anatomny Branch, National Cancer Institute, Bethesda
3 Ophthalmology Branch, National Institute of Neurological Diseases and Stroke

Hamster lens epithelium infected with simian virus 40 underwent transformation in vitro and produced tumors when injected into homologous hosts. Undisturbed lens epithelium in man and experimental animals has not been observed to undergo neoplastic change. The virus-induced tumors contained undifferentiated cells that were either polygonal or spindle-shaped. Their origin from lens epithelium seems certain since it is possible to isolate this unique structure free of connective tissue and blood vessels.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Oncogenesis of the lens in transgenic mice.
K. Mahon, A. Chepelinsky, J. Khillan, P. Overbeek, J Piatigorsky, and H Westphal (1987)
Science 235, 1622-1628
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Science. ISSN 0036-8075 (print), 1095-9203 (online)