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Science 16 May 1969:
Vol. 164. no. 3881, pp. 842 - 843
DOI: 10.1126/science.164.3881.842
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Articles

Digitoxin Poisoning: Prevention by Spironolactone

Hans Selye 1, Miloslav Krajny 1, and Laurent Savoie 1

1 Institute of Experimental Medicine and Surgery, University of Montreal, Montreal, Canada

Spironolactone (Aldactone®) protects the rat against the production of myocardial necroses and other manifestations of digitoxin poisoning.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Spironolactone Attenuates Experimental Uremic Cardiomyopathy by Antagonizing Marinobufagenin.
J. Tian, A. Shidyak, S. M. Periyasamy, S. Haller, M. Taleb, N. El-Okdi, J. Elkareh, S. Gupta, S. Gohara, O. V. Fedorova, et al. (2009)
Hypertension 54, 1313-1320
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Induction of Rat Intestinal P-glycoprotein by Spironolactone and Its Effect on Absorption of Orally Administered Digoxin.
C. I. Ghanem, P. C. Gomez, M. C. Arana, M. Perassolo, G. D. Carpini, M. G. Luquita, L. M. Veggi, V. A. Catania, L. A. Bengochea, and A. D. Mottino (2006)
J. Pharmacol. Exp. Ther. 318, 1146-1152
   Abstract »    Full Text »    PDF »
Mercury Poisoning: Prevention by Spironolactone.
H. Selye (1970)
Science 169, 775-776
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