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Science 16 May 1969:
Vol. 164. no. 3881, pp. 839 - 842
DOI: 10.1126/science.164.3881.839
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Articles

Glucose-6-Phosphate Dehydrogenase Deficient Red Cells: Resistance to Infection by Malarial Parasites

Lucio Luzzatto 1, Essien A. Usanga 1, and Shunmugam Reddy 1

1 Sub-Department of Haematology, University College Hospital, Ibadan, Nigeria

Erythrocyte mosaicism occurs in females heterozygous for glucose-6-phosphate dehydrogenase deficiency. In blood from female children with acute Plasmodium falciparum malaria the parasite rate was 2 to 80 times higher in normal than in deficient erythrocytes. This may be the mechanism whereby the gene for glucose-6-phosphate dehydrogenase deficiency confers selective advantage against malaria to heterozygous females, and thus may have attained the polymorphic frequency occurring in populations living in areas with endemic malaria.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)