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Science 25 April 1969:
Vol. 164. no. 3878, pp. 436 - 437
DOI: 10.1126/science.164.3878.436
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Articles

Serum C'3 Lytic System in Patients with Glomerulonephritis

R. E. Spitzer 1, E. H. Vallota 1, J. Forristal 1, E. Sudora 1, A. Stitzel 1, N. C. Davis 1, and C. D. West 1

1 Children's Hospital Research Foundation, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio

The serums of patients with hypocomplementemic glomerulonephritis contain a substance that combines with a normal serum cofactor in the presence of magnesium ion to specifically cleave the third component of complement. This lysis of C'3 is 80 to 90 percent complete in 20 minutes at 37°C and pH 7. Neither the nephritic factor nor its cofactor is identifiable with the complement system.


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