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Science 25 April 1969:
Vol. 164. no. 3878, p. 426
DOI: 10.1126/science.164.3878.426
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Articles

Potassium, Corticosterone, and Adrenocorticotropic Hormone Release in vitro

Jacob Kraicer 1, J. V. Milligan 1, J. L. Gosbee 1, R. G. Conrad 1, and C. M. Branson 1

1 Department of Physiology, Queen's University, Kingston, Ontario

Incubation of rat adenohypophyses in a high concentration of potassium increases adrenocorticotropic hormone release. This increased release is suppressed by the addition of corticosterone to the incubating medium. Our findings are consistent with a process of "stimulus-secretion coupling" proposed for other glands and suggest that corticosterone may operate directly on the adenohypophysial cell membrane to inhibit releasing mechanisms.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Adenohypophysial Transmembrane Potentials: Polarity Reversal by Elevated External Potassium Ion Concentration.
J. V. Milligan and J. Kraicer (1970)
Science 167, 182-184
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