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Science 25 April 1969:
Vol. 164. no. 3878, pp. 424 - 426
DOI: 10.1126/science.164.3878.424
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Articles

White Blood Cell Cultures in Genetic Studies on the Human Mucopolysaccharidoses

Kathleen M. Foley 1, B. Shannon Danes 1, and Alexander G. Bearn 1

1 Division of Human Genetics, Department of Medicine, Cornell University Medical College, New York 10021

Cultures of white cells derived from peripheral blood of individuals homozygous and heterozygous for the inherited mucopolysaccharidoses revealed a distinct intracellular metachromatic staining with toluidine blue O. These short-term cultures circumvent the technical problems of skin fibroblast cultures and provide a simple screening procedure to detect the heterozygous state for the mucopolysaccharidoses, as well as offering an opportunity to study the heterozygous state of various inherited storage diseases.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Inborn Errors of Mucopolysaccharide Metabolism: Faulty degradative mechanisms are implicated in this group of human diseases.
E. F. Neufeld and J. C. Fratantoni (1970)
Science 169, 141-146
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Science. ISSN 0036-8075 (print), 1095-9203 (online)