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Science 11 April 1969:
Vol. 164. no. 3876, pp. 183 - 184
DOI: 10.1126/science.164.3876.183
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Articles

Crystal and Molecular Structure of a Thymine-Thymine Adduct

I. L. Karle 1, Shih Yi Wang 2, and A. J. Varghese 2

1 Naval Research Laboratory, Laboratory for the Structure of Matter, Washington, D.C. 20390
2 Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland 21205

Thymine-thymine adduct is a product isolated from thymine irradiated with ultraviolet light in frozen aqueous solution. This compound is presumably formed through the rearrangement of an initial photoproduct. Single crystal x-ray diffraction analysis has confirmed the molecular formula of the adduct, 5-hydroxy-6-4'-(5'-methylpyrimid-2'-one)-dihydrothymine, except for the possibility of a hydrogen atom on the 3' nitrogren rather than the 1' nitrogen, and has established the stereoconfiguration of the molecule.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Crystal and Molecular Structure of a Thymine Phototrimer.
J. L. Flippen, I. L. Karle, and S. Y. Wang (1970)
Science 169, 1084-1085
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Science. ISSN 0036-8075 (print), 1095-9203 (online)