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Science 28 March 1969:
Vol. 163. no. 3874, pp. 1452 - 1453
DOI: 10.1126/science.163.3874.1452
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Articles

Serine Requirement in Leukemic and Normal Blood Cells

James D. Regan 1, Helen Vodopick 1, Susumu Takeda 1, William H. Lee 1, and Frederick M. Faulcon 1

1 Biology Division, Oak Ridge National Laboratory, and Medical Division, Oak Ridge Associated Universities, Oak Ridge, Tennessee 37830

In a serine-deficient medium, cells from humangt chronic granulocytic leukemia and normal human bone marrow exhibited a marked inhibition of incorporation of-radioactive precursors of DNA, RNA, and protein into an acid insoluble cell fraction. Normal diploid human fibroblasts did not exhibit inhibition without serine. Chronic granulocytic leukemia and normal marrow cells were essentially unable to synthesize C14-serine from C14-glucose, while human diploid fibroblasts were highly capable of this synthesis.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)