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Science 14 March 1969:
Vol. 163. no. 3872, pp. 1193 - 1194
DOI: 10.1126/science.163.3872.1193
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Articles

Subacute Sclerosing Panencephalitis: Propagation of Measles Virus from Brain Biopsy in Tissue Culture

Tsu Teh Chen 1, Itaru Watanabe 2, Wolfgang Zeman 2, and John Mealey Jr. 3

1 Division of Neurosurgery, Indiana University Medical Center, Indianapolis 46202
2 Division of Neuropathology
3 Division of Neurosurgery

Measles virus was propagated in monolayer cultures established from brain tissue of a patient with subacute sclerosing panencephalitis. Syncytial cells were rendered fluorescent with measles specific antiserums only, by means of an indirect technique. The ultrastructural appearance of the microtubular aggregates was identical in brain tissue and in the cultured cells. Fusion experiments produced a cytopathic effect in humnan embryonic kidney and VERO cell cultures. The virus was identified by hemiagglutination-inhibition, but only in the supernatant of disrupted cultured cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Measles virus nucleotide sequences: detection by hybridization in situ.
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Nonviral Intranuclear Filamentous Inclusions.
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The Uvea.
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Arch Ophthalmol 85, 624-635
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Hemolytic-Uremic-Like Syndrome Following Polycarboxylate Interferon Induction: Treatment of Dawson's Inclusion-Body Encephalitis.
T. J. Leavitt, T. C. Merigan, and J. M. Freeman (1971)
Arch Pediatr Adolesc Med 121, 43-47
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Ophthalmic Manifestations of Subacute Sclerosing Panencephalitis.
R. M. Robb and G. V. Watters (1970)
Arch Ophthalmol 83, 426-435
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