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Science 7 March 1969:
Vol. 163. no. 3871, pp. 1079 - 1081
DOI: 10.1126/science.163.3871.1079
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Articles

Leukotactic Factor Produced by Sensitized Lymphocytes

Peter A. Ward 1, Heinz G. Remold 2, and John R. David 2

1 Armed Forces Institute of Pathology, Washington, D.C. 20305
2 Robert B. Brigham Hospital, Harvard Medical School, Boston, Massachusetts 02120

Lymph node lymphocytes obtained from guinea pigs exhibiting delayed hypersensitivity are stimulated in vitro by specific antigen to produce a soluble factor that is chemotactic in vitro for mononuclear macrophages. The material is nondialyzable, relatively heat stable, and elutes from Sephadex G-100 in the fraction containing molecules smaller than immunoglobulins.


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R. G. CRYSTAL, W. C. ROBERTS, G. W. HUNNINGHAKE, J. E. GADEK, J. D. FULMER, and B. R. LINE (1981)
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Selected Reiews of the Literature.
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