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Science 7 March 1969:
Vol. 163. no. 3871, pp. 1078 - 1079
DOI: 10.1126/science.163.3871.1078
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Articles

Mammalian Oocytes: X Chromosome Activity

Charles J. Epstein 1

1 Department of Pediatrics, University of California Medical Center, San Francisco 94122

The glucose-6-phosphate dehydrogenase and lactate dehydrogenase contents of oocytes from XO and XX female mice have been measured. The activity of the former in the oocytes of XO mice is half of that in the oocytes of XX mice, whereas the lactate dehydrogenase activities in the two groups of ova are the same. These results indicate that glucose-6-phosphate dehydrogenase from a mouse oocyte is an X-linked enzyme, that its synthesis occurs in the oocyte and is dosage dependent, and that inactivation of the X chromosome does not occur in the mouse oocyte.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Human Chromosome 21 Dosage: Effect on the Expression of the Interferon Induced Antiviral State.
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Expression of the Mammalian X Chromosome before and after Fertilization.
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