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Science 14 February 1969:
Vol. 163. no. 3868, pp. 689 - 691
DOI: 10.1126/science.163.3868.689
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Articles

Cycasin: Detection of Associated Mutagenic Activity in vivo

M. G. Gabridge 1, A. Denunzio 1, and M. S. Legator 1

1 Cell Biology Branch, Division of Nutrition, Food and Drug Administration, Department of Health, Education, and Welfare, Washington, D.C. 20204

Cycasin and its lagycone, methylazoxymethanol, increase the mutant frequency of Salmonella typhimurium histidine auxotrophs when tested in the hostmediated assay. As expected, the degree of cycasin-related mutagenic activity depends on the facility with which the compound can be enzymatically deglucosylated by the normal intestinal flora.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Hycanthone: A Frameshift Mutagen.
P. E. Hartman, K. Levine, Z. Hartman, and H. Berger (1971)
Science 172, 1058-1060
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