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Science 14 February 1969:
Vol. 163. no. 3868, pp. 686 - 687
DOI: 10.1126/science.163.3868.686
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Articles

Fast Transport System of Materials in Mammalian Nerve Fibers

S. Ochs 1, M. I. Sabri 1, and J. Johnsona 1

1 Indiana University Medical Center, Indianapolis 46202

A fast transport system of materials is shown in cat sensory fibers of sciatic nerve. After injection of tritiated leucine into the lumbar seventh ganglia, the distribution of activity was measured in the sciatic nerves from 2 to 8 hours afterward. The distribution showed a crest of activity advancing down the fibers at a rate of approximately 410 millimeters per day. An intraaxonic locus of the activity was indicated by a block of the downflow induced by local freezing which causes the fibers to close off. Some of the activity in the nerve was due to free tritiated leucine, with most of it incorporated into polypeptide, soluble protein, and subcellular particulates.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Functional Micro-Anatomy of the Peripheral Nerve Trunks.
K. KUCZYNSKI (1974)
J Hand Surg Eur Vol. 6, 1-10
   PDF »
Fast Transport of Materials in Mammalian Nerve Fibers.
S. Ochs (1972)
Science 176, 252-260
   PDF »
Metabolic Dependence of Fast Axoplasmic Transport in Nerve.
S. Ochs and N. Ranish (1970)
Science 167, 878-879
   Abstract »    PDF »


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