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Science 7 February 1969:
Vol. 163. no. 3867, pp. 578 - 579
DOI: 10.1126/science.163.3867.578
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Articles

Collagen Has a Discrete Family of Reactive Hydroxylysyl and Lysyl Side-Chain Amino Groups

Roy C. Page 1 and Earl P. Benditt 1

1 Department of Pathology, University of Washington, School of Medicine, Seattle 98105

Several cross-linking substances which derive from lysine have been isolated from hydrolyzates of collagen and elastin. This observation suggests that certain lysyl side chains exhibiting enhanced reactivity and unique configuration may participate in cross-linking. In native collagen there is a small family of lysyl and hydroxylysyl side chains which exhibit a high propensity of Schiff base formation.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)