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Science 31 January 1969:
Vol. 163. no. 3866, pp. 474 - 475
DOI: 10.1126/science.163.3866.474
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Articles

Complement-Immunoglobulin Relation: Deficiency of C'lq Associated with Impaired Immunoglobulin G Synthesis

Peter F. Kohler 1 and Hans J. Muller-Eberhard 2

1 Department of Medicine, University of Colorado Medical Center, Denver 80220
2 Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037

Concentration of the complement protein C'lq was determined immunochemically in serums of individuals with a wide variety of immunoglobulin abnormalities. A significant correlation was observed between decreased concentration of C'lq and deficient synthesis of immunoglobulin G; C'lq was particularly diminished in subjects with congenital, sex-linked (Bruton) agammaglobulinemia. In contrast, two to five times the normal concentration of C'lq was found in the serum of three patients with heavy chain disease (subtype immunoglobulin G3). No significant relation was found between C'lq and concentrations of immunoglobulins A and M.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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