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Science 17 January 1969:
Vol. 163. no. 3864, pp. 286 - 288
DOI: 10.1126/science.163.3864.286
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Articles

Human C'3: Evidence for the Liver as the Primary Site of Synthesis

Chester A. Alper 1, A. Myron Johnson 1, Alan G. Birtch 2, and Francis D. Moore 2

1 Blood Grouping Laboratory and Children's Hospital Medical Center, Boston, Massachusetts 02115
2 Peter Bent Brigham Hospital, Boston, Massachusetts 02115

The liver is the primary, if not sole, site of synthesis of the third component of human complement, as shown by a change in the recipient from C'3 FS0.6 to C'3 SS, the donor type, following homotransplantation of the liver.


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