Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 10 January 1969:
Vol. 163. no. 3863, pp. 188 - 190
DOI: 10.1126/science.163.3863.188
Prev | Table of Contents | Next

Articles

Hemophilia: Role of Organ Homografts

T. L. Marchioro 1, C. Hougie 1, H. Ragde 1, R. B. Epstein 1, and E. D. Thomas 1

1 University of Washington School of Medicine, Departments of Surgery, Pathology, and Medicine, Seattle 98105

The concentration of factor VIII and partial thromboplastin times became normal and have remained normal for 140 days after orthotopic tranplantation of a normal liver to a hemophilic dog. Transplantation of a normal spleen into a hemophilic recipient did not result in a significant increase in factor VIII although the splenic graft was viable for at least 47 days. Transplantation of normal marrow to a lethally irradiated hemophilic dog did not result in an increase in factor VIII during 34 days of observation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The therapeutic effect of bone marrow-derived liver cells in the phenotypic correction of murine hemophilia A.
N. Yadav, S. Kanjirakkuzhiyil, S. Kumar, M. Jain, A. Halder, R. Saxena, and A. Mukhopadhyay (2009)
Blood 114, 4552-4561
   Abstract »    Full Text »    PDF »
Correction of hemophilia as a proof of concept for treatment of monogenic diseases by fetal spleen transplantation.
A. Aronovich, D. Tchorsh, H. Katchman, S. Eventov-Friedman, E. Shezen, U. Martinowitz, B. R. Blazar, S. Cohen, O. Tal, and Y. Reisner (2006)
PNAS 103, 19075-19080
   Abstract »    Full Text »    PDF »
Factor VIII expression in azoxymethane-induced murine fulminant hepatic failure.
C. B. Doering, C. D. Josephson, H. N. Craddock, and P. Lollar (2002)
Blood 100, 143-147
   Abstract »    Full Text »    PDF »
Expression of Factor VIII by Murine Liver Sinusoidal Endothelial Cells.
H. Do, J. F. Healey, E. K. Waller, and P. Lollar (1999)
J. Biol. Chem. 274, 19587-19592
   Abstract »    Full Text »    PDF »
von Willebrand Factor Elevates Plasma Factor VIII Without Induction of Factor VIII Messenger RNA in the Liver.
R. J. Kaufman, A. J. Dorner, and D. N. Fass (1999)
Blood 93, 193-197
   Abstract »    Full Text »    PDF »
The Life Cycle of Coagulation Factor VIII in View of Its Structure and Function.
P. J. Lenting, J. A. van Mourik, and K. Mertens (1998)
Blood 92, 3983-3996
   Full Text »    PDF »
The Role of the Splenic Macrophage in Antihemophilic Factor (Factor VIII) Synthesis.
R. B. Ponn, E. A. Kellogg, J. M. Korff, C. A. S. Pegg, H. S. Sise, and J. C. Norman (1971)
Arch Surg 103, 398-401
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)