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Science 3 January 1969:
Vol. 163. no. 3862, pp. 88 - 90
DOI: 10.1126/science.163.3862.88
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Articles

Intellectual Deficit Associated with Transplacentally Induced Microcephaly in the Rat

R. K. Haddad 1, Ausma Rabe 1, Gert L. Laqueur 2, Maria Spatz 2, and Marius P. Valsamis 3

1 New Jersey Neuropsychiatric Institute, Box 1000, Princeton 08540
2 National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland 20014
3 Brooklyn State Hospital, Brooklyn, New York

Fischer rats injected with methylazoxymethanol late in pregnancy produce young with considerably reduced cerebral hemispheres. They appear normal otherwise. As adults these animals make many more errors in the Hebb-Williams maze than do control animals.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neurobehavioral Assessment: A Survey of Use and Value in Safety Assessment Studies.
L. D. Middaugh, D. Dow-Edwards, A. A. Li, J. D. Sandler, J. Seed, L. P. Sheets, D. L. Shuey, W. Slikker Jr., W. P. Weisenburger, L. D. Wise, et al. (2003)
Toxicol. Sci. 76, 250-261
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Neuronal migration disorders: Heterotopic neocortical neurons in CA1 provide a bridge between the hippocampus and the neocortex.
N. Chevassus-Au-Louis, P. Congar, A. Represa, Y. Ben-Ari, and J.-L. Gaiarsa (1998)
PNAS 95, 10263-10268
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A Case of Adult Microcephaly.
E. C. Dooling and E. P. Richardson Jr (1980)
Arch Neurol 37, 688-692
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Methylazoxymethanol treatment of fetal rats results in abnormally dense noradrenergic innervation of neocortex.
M. Johnston, R Grzanna, and J. Coyle (1979)
Science 203, 369-371
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