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Science 3 January 1969:
Vol. 163. no. 3862, pp. 81 - 82
DOI: 10.1126/science.163.3862.81
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Articles

Giant Hepatic Mitochondria: Production in Mice Fed with Cuprizone

Kinuko Suzuki 1

1 Department of Pathology (Neuropathology), Albert Einstein College of Medicine, Bronx, New York 10461

Giant mitochondria in hepatocytes that have the average size of nuclei can be consistently produced in the liver of weanling mice by feeding them cuprizone (bis-cyclohexanone oxaldihydrazone). The simplicity of the procedure and the consistency of the results make the feeding of cuprizone a new and useful experimental tool for the study of mitochondrial metabolism.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Euglena gracilis: Formation of Giant Mitochondria.
R. Calvayrac, F. Van Lente, and R. A. Butow (1971)
Science 173, 252-254
   Abstract »    PDF »
A New Mitochondrial Myopathy in a Patient With Salt Craving.
A. J. Spiro, J. W. Prineas, and C. L. Moore (1970)
Arch Neurol 22, 259-269
   Abstract »    PDF »


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