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Science 3 January 1969:
Vol. 163. no. 3862, pp. 79 - 81
DOI: 10.1126/science.163.3862.79
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Articles

Induction of Brain D(m)-beta-Hydroxybutyrate Dehydrogenase Activity by Fasting

Arnold L. Smith 1, H. Sherwood Satterthwaite 1, and Louis Sokoloff 1

1 Section on Cerebral Metabolism, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland

D(m)-beta-hydroxybutyrate dehydrogenase activity is very low in normal adult rat brain; but during fasting it increases severalfold in parallel with the ketosis. The increase may represent part of a mechanism by which the brain adapts to changing patterns of substrate supply during starvation.


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